"Kill me, I pray You, out of hand"
Rabbi Shimon tells Rabbi Yitzchak that Moses was addressing the place where death prevails; he was speaking to the Tree of Death, thus he used the feminine form of "You." God granted him his wish to die by not letting him enter the Holy Land. It is therefore ill advised for a person to curse himself when he is angry because his curse will come true. Rabbi Shimon points to Moses' total humility, and that he ascended over all the elevated prophets.